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Concomitant use of SARAFEMfluoxetinein patients taking MAOIs is contraindicatedThere have been reports of serioussometimes fatalreactionsincluding hyperthermiarigiditymyoclonusautonomic instability with possible rapid fluctuations of vital signsand mental status changes that include extreme agitation progressing to delirium and comain patients receiving fluoxetine in combination with a monoamine oxidase inhibitorMAOIand in patients who have recently discontinued fluoxetine and are then started on an MAOISome cases presented with features resembling neuroleptic malignant syndromeThereforefluoxetineincluding SARAFEMshould not be used in combination with an MAOIor within a minimum of 14 days of discontinuing therapy with an MAOIsee CONTRAINDICATIONSSince fluoxetine and its major metabolite have very long elimination half-livesat least 5 weeksperhaps longerespecially if fluoxetine has been prescribed chronically and/or at higher dosesshould be allowed after stopping fluoxetine before starting an MAOIsee DOSAGE AND ADMINISTRATIONCONTRAINDICATIONSWARNINGS AND PRECAUTIONSand CLINICAL PHARMACOLOGY

Get emergency medical help if you have any of these signs of an allergic reactionskin rash or hivesdifficulty breathingswelling of your facelipstongueor throat.

Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapyFluoxetine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetussee Use In Specific Populations

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