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There have been rare postmarketing reports of severe liver injury with hepatocellular necrosis or acute hepatic failure in patients treated with XENICALwith some of these cases resulting in liver transplant or deathPatients should be instructed to report any symptoms of hepatic dysfunctionanorexiapruritusjaundicedark urinelight-colored stoolsor right upper quadrant painwhile taking XENICALWhen these symptoms occurXENICAL and other suspect medications should be discontinued immediately and liver function tests and ALT and AST levels obtained.

Patients should be strongly encouraged to take a multivitamin supplement that contains fat-soluble vitamins to ensure adequate nutrition because XENICAL has been shown to reduce the absorption of some fat-soluble vitamins and beta-carotenesee DOSAGE AND ADMINISTRATIONand ADVERSE REACTIONSIn additionthe levels of vitamin D and beta-carotene may be low in obese patients compared with non-obese subjectsThe supplement should be taken once a day at least 2 hours before or after the administration of XENICALsuch as at bedtime.

Never share this medicine with another personespecially someone with a history of eating disorders.

Loose stoolsor an urgent need to go to the bathroominability to control bowel movements;

Orlistat is a reversible inhibitor of gastrointestinal lipasesIt exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipasesThe inactivated enzymes are thus unavailable to hydrolyze dietary fat in the form of triglycerides into absorbable free fatty acids and monoglyceridesAs undigested triglycerides are not absorbedthe resulting caloric deficit may have a positive effect on weight control.

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patent protection for xenical, originally to end on 18 june 2004, was extended by five years until 2009 by the u.

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